When using drugs in combination, the synergy between drugs should be utilized to avoid incompatibility. Generally speaking, the above-mentioned synergistic or antagonistic effects will also occur when many antibiotics are used in combination.

Antibacterial drugs can be divided into two categories according to their properties:

The first category is bactericidal antibiotics. Including penicillin series, cephalosporin, aminoglycosides, bacitracin, and polymyxins, etc.; when the first class of antibiotics are used together, the bactericidal effect will be enhanced or additive.

The second category is antibacterial antibiotics. Including chloramphenicol, tetracycline, erythromycin, oxytetracycline, sulfa, etc.; when the second type of antibiotics are used together, the antibacterial effects can be additive, but there will be no enhanced bactericidal effect.

Special note: Combination of first-class and second-class antibiotics can produce antagonistic effects.

In addition, interactions may also occur when antibiotics are mixed with other drugs. For example: sulfonamides and trimethoprim (TMP), Xinjiangerate and potassium permanganate, hydrogen peroxide and glacial acetic acid, rhubarb and ammonia, etc. can produce synergistic effects to increase the efficacy of the medicine. Metal ions such as aluminum, magnesium, calcium, and iron in tetracyclines and antacid drugs can form chelates, making it difficult for intestinal absorption, thus reducing the effect of antibiotics, so special attention should be paid.

Turtle medicine has its uniqueness in the use method, so most external medicines will be affected by the water medium to some extent. When multiple medicines are used at the same time, they will especially affect each other. obvious.

For example, commonly used quicklime, it is not only combined with copper sulfate, bleaching powder and rich Chlorine has an antagonistic effect and is also affected by phosphorus or ammonium nitrogen in the water. Similarly, phosphorus or ammonium nitrogen will also interact with quicklime and reduce fertilizer efficiency. Therefore, it should be staggered for 5 to 7 days when used in production.

Also, the commonly used mixture of copper sulfate and ferrous sulfate also uses the synergy between drugs to better exert its efficacy. However, when copper sulfate meets alkaline water or with table salt, it will Produce antagonism between drugs and affect drug efficacy.

Therefore, when using multiple drugs to comprehensively prevent and treat diseases, we must pay attention to the antagonism and synergy between them, and determine the use of drugs and increase or decrease their dosage according to the specific situation.