Vaccinations can begin for kittens as young as two months old. Typically, kittens receive their first dose of vaccine when they are 6 to 8 weeks old, followed by boosters every 2 to 4 weeks until they are approximately 16 weeks old. This vaccination program helps protect kittens from common diseases such as feline distemper virus, feline respiratory disease, and rabies.

Before vaccination, the kitten should have received a proper physical examination and confirmed health Good health. Additionally, kittens typically acquire passive immunity, known as maternal antibodies, from their mother during the first few weeks of life, and these antibodies can provide temporary protection. As kittens age, these maternal antibodies gradually disappear, so vaccination is needed to activate the kitten's own active immune system.