1. Disease factors that cause immunosuppression in pigs

1. Viral factors

(1) Porcine reproductive and respiratory syndrome (PRRS) PRRS virus mainly occurs in mononuclear giant virus Replicates within the phagocyte system, especially alveolar macrophages. Then it is transferred to local lymphoid tissue and further spreads to macrophages and monocytes in many tissues throughout the body, reducing the immunity of the infected pigs, causing immunosuppression and immune interference, thereby secondary to other pathogenic infections, resulting in higher Morbidity and Mortality.

(2) Porcine Circovirus (PCV) Porcine circovirus type 2 (PCV-2) can cause porcine postweaning multisystem wasting syndrome (PMWS), neonatal piglet congenital tremor (CT), porcine proliferative and necrotizing pneumonia (PNP), porcine interstitial Pneumonia (1P), porcine dermatitis and nephrotic syndrome (PDNS), porcine respiratory syndrome (PRDC), and sow reproductive failure, etc. Although the mechanism of PCV-2 causing immunosuppression in pigs is not yet clear, the results of studies on various diseases caused by PCV-2 show that there is a loss of lymphoid follicles in both the lymphoid follicular center and the accessory follicular center. The injured lymphoid tissue is infiltrated by histiocytes and multinucleated giant cells, which can cause cell apoptosis and decrease in B and T cells. PCV-2 infected pigs are usually accompanied by the occurrence of other diseases, such as pseudorabies, PRRS, porcine parvovirus, and streptococcosis in pigs. (3) Classical swine fever virus initially replicates in the tonsils, and then moves to peripheral lymph nodes. After replicating in local lymph nodes, it reaches the peripheral blood, where it multiplies in large numbers in the spleen, bone marrow, visceral lymph nodes and small intestinal lymphoid tissues, destroying the body's immune system. white blood cells and monocytes, thereby destroying the immune response of the animal body and leading to the invasion of other pathogenic microorganisms.

(4) Swine influenza virus (SIV) Some SIV can cause serious damage to pig immune organs, a large number of lymphocytes, and can also cause immune cells produced by B cells after stimulation with exogenous antigens. The protein structure and antigen reactivity change; some SIV can cause a significant reduction in the conversion rate of peripheral blood T lymphocytes and cause hemorrhagic changes in the spleen, thymus and cecal tonsils, thereby significantly inhibiting the cellular immune function of pigs. In addition, SIV mainly invades porcine respiratory epithelial cells and proliferates there, eventually leading to epithelial cell shedding, necrosis, and neutrophil infiltration in the lungs, blocking the respiratory tract and damaging lung tissue.

2. Bacterial factors and other pathogenic microorganisms

(1). Porcine infectious pleuropneumonia (APP) Actinomycete pleuropneumoniae mainly colonizes the respiratory tract of pigs and has a high degree of Host specificity. Experiments have confirmed that the bacterium settles in tonsils and adheres to the alveolar epithelium. It can be rapidly engulfed or adsorbed by alveolar macrophages and produce toxins. These cytotoxins are potentially toxic to alveolar macrophages, pulmonary endothelial cells and epithelial cells.

(2) Porcine epierythrozoidosis can cause autoimmune hemolytic anemia. Epierythrozoites interact with red blood cell membranes, causing red blood cells to rupture or deform, thereby destroying the body's red blood cell immune mechanism and easily causing secondary infections from other pathogens. It has been reported that porcine eperythrozoidosis may be related to immunosuppression, but further confirmation is needed.

(3) Porcine toxoplasmosis It has been confirmed that during the process of Toxoplasma propagating in the host body, a large number of immune cells are damaged by Toxoplasma, destroying the body's immune system, eventually leading to immune suppression.

3. Physical and chemical factors Heavy metals (such as mercury, lead, etc.), industrial chemicals (such as excessive fluorine), etc. can poison and interfere with the normal physiological functions of the body’s immune system. Excessive intake will cause immune tissue damage. Organ activity is reduced, and antibody production is reduced; large amounts of radiation or large doses of ultraviolet irradiation of animals can kill bone marrow stem cells and destroy their bone marrow function. As a result, hematopoietic stem cells are severely damaged, resulting in the loss of hematopoietic and immune functions.

2. How to improve the immunity of pigs, eliminate immune suppression, enhance disease resistance, and reduce disease losses?

It is very important for the long-term stable development of pigs to formulate reasonable immune procedures, rationally use health-care drugs, strengthen feeding and management, and use genuine traditional Chinese medicine immunomodulators to improve the resistance of pigs and eliminate immunosuppression. .

Leading technology and the first of its kind in the country, Shibilong uses modern supercritical extraction and high-precision purification and granulation technology to combine with the wisdom of traditional Chinese medicine experts. After several years of hard research and development and clinical trials on countless pig farms, Qizhen Zengwu Granules were successfully developed, with faster absorption and higher bioavailability. This innovative product has historical significance.

3. Main ingredients of Qizhen Zengwu Granules< /p>

Astragalus, Epimedium, Ligustrum lucidum, etc.

IV. Characteristics of Qizhen Zengwu Granules

1. It has the functions of enhancing the body’s immune function, enhancing vaccine immune response, promoting antibody formation and anti-viral and anti-stress functions, and repairing Immunodeficiency caused by various causes.

2. The drug of choice for effective defense against various drug-, toxin-, and pathogenic immunosuppressive diseases.

3. Supercritical extraction and high-precision purification and granulation ensure faster absorption and higher bioavailability.

4. Pure Chinese medicine, high content, safe and efficient, green and environmentally friendly, without any toxic or side effects.

5. Usage directions of Qizhen Zengwu Granules

1. Prevention and cooperative treatment of various immunosuppressive diseases: porcine hyperthermia syndrome, porcine blue-ear disease, porcine circovirus Type II infections (weaned pig multisystem wasting syndrome, porcine dermatitis nephrotic syndrome), swine influenza, swine fever, foot and mouth disease, pseudorabies and other viral diseases; Haemophilus parasuis, porcine contagious pleuropneumonia, Streptococcus suis Bacterial diseases such as swine paratyphoid fever, swine paratyphoid fever, swine asthma, swine eperythrozoonosis, etc.

Cooperate in the prevention and control of avian influenza, Newcastle disease, infectious bursal disease, avian colibacillosis, chicken coccidiosis, etc.

2. The use of this product with vaccines can not only significantly increase the antibody titer of the vaccine, but also timely replenish the immune antibodies during the immune window.

3. Effectively remove mycotoxins, drug-induced immunosuppression, low immune function after major epidemics, and reduced immunity caused by various stresses. Long-term addition can significantly improve fecundity and survival rate, promote growth and development, reduce feed-to-meat ratio, and improve production efficiency.

VI. Usage and dosage of Qizhen Zengwu Granules

1. Prevention: Mixed feeding of pigs and poultry, 500g mixed with 1000Kg feed, pigs should be used for 10-15 days, and poultry should be used for 10 days day.

Mix to drink, add 250g to 1 ton of water. Use it continuously for 7-10 days for pigs and 5-7 days for poultry. Long-term feeding of this product has the effect of health promotion, growth promotion and disease prevention.

2. Treatment: Pigs and poultry are fed mixedly, 1000g mixed with 500Kg feed, pigs are used for 10 days, and poultry are used for 7 days.

1000g of drinking water mixed with 1 ton of water. Use it for 10 days in a row for pigs and 7 days in a row for poultry.