Canine NT-proBNP

NT-proBNP is cleaved from BNP produced by cardiomyocytes. When cardiac insufficiency occurs, myocardial cells are stimulated by excessive stretch and will produce more NT-proBNP. NT-proBNP is an important indicator for detecting heart failure. It is a heart failure marker and has a longer half-life, making it difficult to miss diagnosis.

Canine troponin I (cTnI) is a protein in cardiac muscle fibers. When myocardial damage occurs, the cardiomyocytes rupture, cTnI is released and enters the blood circulation system. cTnI levels will increase. cTnI is one of the most sensitive and specific serum markers of myocardial cell damage. The concentration of troponin I in peripheral blood is measured to reflect the degree of myocardial damage.

Clinical applications of canine NT-proBNP and canine troponin I:

1. Identification of congenital genetic heart disease and assessment of cardiac function in elderly dogs

3. Monitoring treatment efficacy and prognosis assessment, and adjusting treatment plans

4. Assessment of cardiovascular health status of dogs and cats< /p>

Canine Cystatin C

Cystatin C (Cys C) is an important indicator for detecting renal function. It belongs to the cysteine ​​protease inhibitor family of proteins and can be inhibited by all Nucleated cells are synthesized at a relatively stable rate, and their blood concentration is not affected by age, gender, race and muscle mass, and is only metabolized by the kidneys. It is an endogenous source of glomerular filtration rate with good sensitivity and high specificity. Sexuality markers (GFR).

Clinical application:

1. Screening for congenital kidney disease and early assessment of kidney injury

2. Routine physical examination

3. Surgery Assessment of anterior renal function

4. Assist in the diagnosis of other diseases (for pets with diabetes, screen for diabetic nephropathy)

D-dimer

D-dimer (D-dimer) is a degradation product of cross-linked fibrin and an important marker of activation of the coagulation and fibrinolytic systems in the body. The most widely used clinical value lies in the exclusion diagnosis of deep vein thrombosis and pulmonary embolism.

Clinical application:

1. Physical examination of pets (evaluating blood conditions)

2. Pets showing symptoms such as swelling, pain, and redness of lower limbs (suspected deep veins Thrombosis)

3. Difficulty breathing, chest pain, cough, and hemoptysis (suspected pulmonary artery thrombosis)

4. Evaluate the formation of thrombus after surgery

Triton The significance of the canine myocardial quadruple test

1. cNT-probnp and cTnI can detect and diagnose whether dogs have heart failure, myocardial infarction, myocarditis and other heart diseases.

The more common acquired heart diseases in dogs are valvular heart disease and dilated cardiomyopathy.

① Canine valvular heart disease is clinically more common in the mitral valve. Mitral valve myxomatous degenerative disease (MMVD) is the most common heart disease in dogs, accounting for 75%-80% of canine heart disease. , mostly occurs in small dogs and middle-aged and elderly dogs. It can cause heart failure, often manifested by coughing, wheezing, and difficulty breathing.

② Dilated cardiomyopathy DCM is more common in large or giant dogs, and the incidence rate is higher in middle-aged and elderly male dogs than in female dogs. The disease is characterized by ventricular cavity dilation (left ventricular or bilateral ventricular dilation) and systolic dysfunction, often leading to congestive heart failure. Its main feature is a decrease in myocardial contractility, usually accompanied by tachycardia.

2. When a dog is diagnosed with heart disease or heart problems, it will affect blood flow and reduce blood flow to the kidneys, which may lead to acute renal failure or decreased kidney function. The level of Cys-C Elevated levels can detect the presence of kidney disease and can also be used in conjunction with other indicators to assess the risk of cardiovascular disease in dogs.

3. Dogs suffering from heart disease and kidney disease will increase the risk of thrombosis, especially canine dilated cardiomyopathy, which is prone to pulmonary artery thrombosis. In addition, it may also cause stroke or other vascular problems in dogs. . When dogs suffer from specific diseases (heart disease, kidney disease, etc.), the blood clot marker D-Dimer should be screened.

Summary

Heart disease is one of the more common cardiovascular diseases in dogs. You need to always pay attention to the status of your dog in life, especially those with high incidence or those entering old age. For dogs, it is very necessary to conduct systematic and systematic screening and physical examinations on your dogs on a regular basis.

Joint detection of cNT-proBNP, ccTnI, cCys-C and D-Dimer in the myocardial quadruple linkage of Triton dogs - can comprehensively and effectively evaluate the cardiovascular health status of dogs. A screening of the canine myocardial quadruple test card can help veterinarians diagnose whether dogs are at risk of heart disease, kidney disease and blood clots. It can also help doctors provide early treatment and guide scientific medication use.

K9 multi-channel multiple detection immunofluorescence analyzer

Introduction

Hivit K9 multi-channel multi-detection immunofluorescence analyzer uses fluorescence immunochromatography technology and supporting detection reagents to Quantitative detection and analysis of test substances in pet whole blood, serum, plasma, secretions, feces and other samples.

It has 7 independent testing channels and currently supports testing of 40+ items, covering multiple testing items such as dog and cat myocardium, physical examination, antibodies, digestive tract, inflammation, parasites and infectious diseases.

Performance characteristics

01. Multi-channel multi-joint detection, with 7 independent detection channels, supports simultaneous testing of different reagent card types such as single, double, triple and quintuple. Test multiple different test items at the same time;

02. The test time is short and timed independently. The cCRP and fSAA items only take 3 minutes to complete, saving time while reducing workload and error probability;

03. Can be connected to an external code scanner to automatically enter pet information, making it more convenient and efficient;

04. Supports sample testing of whole blood, serum, plasma, feces and secretions;

05. Automatic detection, automatic printing of results, automatic uploading of results, support for data export and intelligent report output;

06. Wide range of applications, suitable for pet hospital clinics, laboratories, clinical departments bedside, etc. Multiple scenarios;

07. Store more than 10,000 pieces of data to meet the needs of large sample sizes and facilitate search;

08. Powerful information management function, can be directly connected to LIS /HIS system;

09. The reagent can be stored at room temperature and is valid for up to 24 months;

10. Smaller in size and takes up less space

Pet Immunization Among fluorescence equipment, multi-channel multi-joint detection has the following advantages compared with single-channel detection:

01 High efficiency, saving time and resources. Multi-channel can process multiple samples at the same time to improve detection efficiency. It saves the time required for single-channel detection. The combined card has a lower overall cost than the sum of single cards, reducing detection costs.

02When there are many samples, the overall accuracy is higher. Although a single channel has a higher accuracy in detecting a single sample, when facing a large number of samples, each sample needs to be detected separately, which will increase the workload and error probability. Multi-channel can detect multiple samples at the same time, reducing operating steps and error probability, and improving overall accuracy.

03 has better scalability. Multi-channel multi-joint detection can detect multiple different indicators at the same time, which can help veterinarians more comprehensively diagnose pathogens or other biomarkers that may be present in samples, increasing the coverage of detection.

04The amount of blood collected is less. The sample volume of multi-channel is compared with that of single channel, and the average amount of blood collected for a single test is less. Each test item only requires an average of 40 μL sample.

05 is more compatible. Multi-channel instruments are fully compatible with single-channel reagents. Printing software for multi-channel and single-channel use, connected to LIS software, the transmission protocol is fully compatible, no additional installation is required.