Gentamicin is an aminoglycoside antibiotic that is mainly used to treat bacterial infections, especially those caused by Gram-negative bacteria. Gentamicin can bind to the 30S subunit of bacterial ribosomes, thereby preventing bacterial protein synthesis and causing bacterial death. In veterinary clinical practice, gentamicin is often used to treat serious infections caused by sensitive gram-negative bacilli, such as Escherichia coli, Klebsiella spp., Enterobacter spp., Proteus spp., Serratia spp., and Pseudomonas aeruginosa. monas and methicillin-sensitive strains of Staphylococcus aureus. In addition, gentamicin is also used in culture media formulations because it is a heat-stable antibiotic.

The functional indications of gentamicin include but are not limited to:

Escherichia coli, aerogenes, Klebsiella, Proteus mirabilis, some indoloprotebacteria, Pseudomonas aeruginosa, some Neisseria, some non-pigmented Serratia and Shigella, etc. Negative bacteria have antibacterial effects.

It is more sensitive to Staphylococcus aureus among Gram-positive bacteria, while Streptococcus is resistant to it.

Anaerobic bacteria, Mycobacterium tuberculosis, rickettsiae, viruses, and fungi are also often insensitive or resistant to gentamicin.

Gentamicin can be used to treat neonatal sepsis, sepsis, central nervous system infections (including meningitis), urogenital tract infections, respiratory tract infections, gastrointestinal infections (including peritonitis), Conditions such as biliary tract infections, skin, bone, otitis media, sinusitis, soft tissue infections (including burns), and listeriosis.

In veterinary practice, the use of gentamicin should consider its characteristics, Adaptability and possible interactions with other antibiotics, and rational use of drug combinations to improve efficacy and reduce the development of drug resistance. When using, it is also necessary to pay attention to incompatibility, dosage and time of use to prevent drug overdose or poisoning and ensure the health of animals.